SEPT 12 orchestrates the formation of mammalian sperm annulus by 1 organizing SEPT 12 - 7 - 6 - 2 / - 4 core complexes

1 Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of 6 Medicine, Taipei Medical University, Taipei 11031, Taiwan. 2 Graduate Institute of Basic 7 Medical Sciences, 3 Department of Obstetrics and Gynecology, and 4 Department of 8 Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, 9 Tainan 70403, Taiwan. 5 Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi 10 Medical Foundation, New Taipei City 23142, Taiwan. 6 Graduate Institute of Basic Medicine, 11 College of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan. 7 12 Agricultural Biotechnology Research Center, Academia Sinica, Taipei 11529, Taiwan. 8 13 Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung 14 University, Tainan 70403, Taiwan. † These authors contributed equally to this work. 15 16 *Correspondence: phone: +886-6-235-3535 ext. 5262 17 FAX: +886-6-276-6185 18 Email address: [email protected] 19 Running title: SEPT12 orchestrate sperm annulus 20 21 © 2015. Published by The Company of Biologists Ltd.